We constantly receive feedback from readers with questions like this:
What do I do if my doctor will not prescribe Metformin if I’m non-diabetic
What if I’m in great shape. Does Metformin still help? Why?
Unfortunately it appears FEW if any Doctors (other than Dr Brett Osborn) will write patients a script for Metformin. And this honestly BOGGLES the mind.
If you do a simple Google Search <Metformin and Life Extension> here is what comes up:
We have to ask one question.
What in the world is going on?
All of this empirical data about Metformin being a wonder drug for just about every population group but yet a reluctance to write a script for it by most Doctors?
Let’s list its PROVEN and UNDERSTOOD effects (directly from the article Metformin The Anti Aging Miracle Drug:
Metformin – Mechanism of Action
Master Switch which Up-Regulates AMP Kinase
At the risk of boring you with overly technical matters, here is the exact mechanism of how Metformin works its magical benefits. The actions of metformin are intimately related to AMPK, these letters stand for Adenosine Mono- Phosphate Kinase (AMP Kinase), which has been called a metabolic “master switch” involved with energy status of cells, hormone expression and protein synthesis.
Metformin Up-Regulates AMP Kinase Expression.
AMPK Affects Cellular Energy/Biochemistry
If AMPK is turned OFF: (This is BAD)
ATP is consumed
Glucose is burned for energy.
Fatty acids and cholesterol are synthesized.
This is similar to effects of HIGH insulin levels.
If AMPK is Turned ON: (This is GOOD)
ATP is created.
Fatty acids are predominantly consumed for energy.
This is similar to the effects of Caloric Restriction and LOW insulin levels.
AMPK Effects on Key Organ Systems
Pancreas: Decreases insulin secretion.
Liver: Decreases fatty acid and cholesterol synthesis.
Adipose (Storage Fat Tissue): Decreases fatty acid synthesis, increase lipolysis.
Skeletal muscle: Increases fatty acid oxidation, glucose uptake, and glycolysis
Heart muscle: Increases fatty acid oxidation, and glucose uptake
Metformin – Mechanisms of Action
1) Decreases glucose absorption from GI tract. (2)
2) Inhibits hepatic gluconeogenesis (production of sugar by the liver).
3) Increases sensitivity and number of insulin receptors.
4) Increases peripheral glucose uptake
5) Increases fatty acid oxidation.
Oh and there is this too:
Off-Label Uses of Metformin
1) Polycystic ovary syndrome (PCOS)
2) Drug-induced weight gain
3) Cancer Prevention
4) Caloric restriction (CR)-mimetic
Why would anyone interested in maximizing their lifespan while slowing the diseases of aging NOT BE using Metformin?
Be the BEST YOU EVER!